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Your rating has been recorded. Write a review Rate this item: 1 2 3 4 5. Preview this item Preview this item. In this book, Elof Carlson tells the incredible story of the difficult quest to understand how the body forms girls and boys. Carlson's history takes us from antiquity to the present day to detail how each component of human reproduction and sexuality was identified and studied, how this knowledge enlarged our understanding of sex determination, and how it was employed to interpret such little understood aspects of human biology as the origin of intersex births.
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Find a copy in the library Finding libraries that hold this item Reviews Editorial reviews. Publisher Synopsis "Carlson does an excellent job presenting the researchers who, over time, worked out the details of sex determination and differentiation. User-contributed reviews Add a review and share your thoughts with other readers. Be the first.
Add a review and share your thoughts with other readers. Similar Items Related Subjects: 2 Genetic sex determination. Sex Determination Processes. User lists with this item 3 eto items by frthde updated What's more, studies in mice are showing that the balance of sex manifestation can be shifted even after birth; in fact, it is something actively maintained during the mouse's whole life.
“I’m XY and I Know It”: Sex Determination Systems 101
According to the Nature feature, true intersex disorders, such as those from divergent genes or the inability of cellular receptors to respond to hormones, yield conflicting chromosomal and anatomical sex. But these are rare, about 1 in 4, More than 25 genes that affect sex development have now been identified, and they have a wide range of variations that affect people in subtle ways.
Many differences aren't even noticed until incidental medical encounters, such as in the opening scenarios the first was probably caused by twin embryos fusing in the woman's mother's womb; the second by a hormonal disorder. Furthermore, scientists now understand that everyone's body is made up of a patchwork of genetically distinct cells, some of which may have a different sex than the rest. This "mosaicism" can have effects ranging from undetectable to extraordinary, such as "identical" twins of different sexes.
An extremely common instance of mosaicism comes from cells passing over the placental barrier during pregnancy. Men often carry female cells from their mothers, and women carry male cells from their sons. Research has shown that these cells remain present for decades, but what effects they have on disease and behavior is an essentially unstudied question.
Haploid selection, sex ratio bias, and transitions between sex-determining systems
This is an uneasy way to think about bodies in a social world where sex is still defined in binary terms. Legal frameworks rely on being able to classify someone as male or female, and social status is often determined by the sex on a birth certificate. Parents and doctors of intersex infants face thorny ethical questions about potential surgeries, therapies, and how to raise the child. The implications of better understanding and socially recognizing DSDs are huge.
As our understanding of biology continues to advance, our social, legal, and medical systems will have to evolve as well. Check out the Nature feature for a discussion of these problems, as well as more interesting research into the biology of sex.