About this book Stem Cells, Craniofacial Development and Regeneration is an introduction to stem cells with an emphasis on their role in craniofacial development. Section I covers embryonic and adult stem cells with a focus on the craniofacial region, while sections II-IV cover the development and regeneration of craniofacial bone, tooth, temporomandibular joint, salivary glands and muscle.
Author Bios George T. Free Access. Summary PDF Request permissions. Tools Get online access For authors. Email or Customer ID. Conventional MSCs contain various types of cells within adherent culture, resulting in contamination of the MSCs with other cell lineages. Moreover, MSCs show great differences in characteristics between long bones and craniofacial tissue, and these differences should be evaluated in detail in future studies.
Sufficient quantities of purified MSCs from adult tissues for reconstruction of large spaces in the craniofacial region are difficult to collect. Human iPSC technology may be used to overcome this problem. Furthermore, more analyses of MSCs, NCCs, SSCs, and iPSCs are required based on a developmental biological approach, which will be expected to provide evidence-based methods for the treatment of various craniofacial diseases.
The authors thank the members of their laboratory for helpful discussions. Hideyuki Okano is a paid scientific advisor of San Bio Co.
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The other authors have no conflict of interests to declare. Satoru Morikawa and Takehito Ouchi contributed equally to this work. National Center for Biotechnology Information , U. Journal List Stem Cells Int v. Stem Cells Int. Published online Feb Author information Article notes Copyright and License information Disclaimer. Received Dec 11; Accepted Feb 2. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC.
Abstract Craniofacial skeletal tissues are composed of tooth and bone, together with nerves and blood vessels. Introduction Developmental origins are beginning to be elucidated through rigorous studies in stem cell biology. Stem Cells in Craniofacial Research Skeletal tissues are composed of a network of hard tissues, including bone and cartilage.
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Figure 1. Application of Human MSCs in Craniofacial Research Craniofacial connective tissues originate from neural crest-derived ectomesenchyme, which is a source of many craniofacial bone and cartilage structures. Conclusion Skeletal tissues are composed of bone, cartilage, and tendon. Acknowledgments The authors thank the members of their laboratory for helpful discussions.
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Mesenchymal Stem Cells and Craniofacial Regeneration
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Stem Cells in Craniofacial Development and Regeneration
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Tissue Engineering Part A. Santagati F. Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis. Stem Cells in Craniofacial Development and Regeneration. Huang , Irma Thesleff. Stem Cells, Craniofacial Development and Regeneration is an introduction to stem cells with an emphasis on their role in craniofacial development. Divided into five sections, chapters build from basic introductory information on the definition and characteristics of stem cells to more indepth explorations of their role in craniofacial development. Section I covers embryonic and adult stem cells with a focus on the craniofacial region, while sections II-IV cover the development and regeneration of craniofacial bone, tooth, temporomandibular joint, salivary glands and muscle.
Concluding chapters describe the current, cutting-edge research utilizing stem cells for craniofacial tissue bioengineering to treat lost or damaged tissue. Cranial neural crest cells in craniofacial tissues. Craniofacial lntramembranous bone. Temporomandibular Joint Development. Craniofacial muscle development.