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Download references. The authors would like to thank the support staff at Cheri-Hill Kennel and Supply and at TRS Labs for their assistance with the conduct of the laboratory studies. We thank the Veterinarians and their clinical staff for their participation in the clinical field study. Doug Rugg is acknowledged for assistance in drafting the manuscript.
KK drafted the manuscript. All authors were involved in protocol development, data interpretation and preparing the manuscript. All authors read and approved the final manuscript. Correspondence to Kristina Kryda. The laboratory study protocols were reviewed and approved by the relevant test facility Animal Care and Use Committee prior to implementation.
The clinical field study protocol was reviewed and approved by the Zoetis Ethical Review Board and owner consent to participate was obtained prior to patient enrolment. These studies were funded by Zoetis. MU and JWM were contracted study investigators. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and Permissions.
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Dog Diarrhea Causes and Remedies - Whole Dog Journal
Research Open Access Published: 11 September Laboratory and field studies to investigate the efficacy of a novel, orally administered combination product containing moxidectin, sarolaner and pyrantel for the prevention of heartworm disease Dirofilaria immitis in dogs Kristina Kryda 1 , Robert H. Six 1 , Kelly F. Walsh 1 , Susan J. Holzmer 1 , Sara Chapin 1 , Sean P. McCall 3 , Tom L. Abstract Background Dirofilaria immitis is a filarial parasite of dogs that can cause serious or fatal cardiopulmonary disease. Methods In two laboratory studies, dogs 8 per group that had been inoculated 30 days prior with 50 third-stage D.
Results In the laboratory studies, there were no heartworms recovered from any dog treated with the combination product or moxidectin alone and all dogs treated with placebo or sarolaner-alone were infected with 20—44 adult heartworms. Conclusions In laboratory studies, no heartworms were recovered from dogs treated with a single dose of the novel combination product containing moxidectin, sarolaner and pyrantel.
Background Heartworm Dirofilaria immitis is a filarial parasite transmitted by mosquitoes that can cause severe and life-threatening disease in dogs and other animals [ 1 , 2 ]. Methods Laboratory studies Two masked, negative placebo-controlled, randomized, laboratory efficacy studies were conducted. Animals Male and female purpose-bred Beagle dogs that had been reared in a mosquito-proof facility were used for these studies. Design Day 0 was designated as the day that dogs received the experimental treatment. Strains and infection The D.
Treatment On Day 0, dogs were dosed with either placebo tablets containing inert formulation ingredients vehicle , combination product chewable tablets Study 1 and 2 or tablets containing sarolaner-alone or moxidectin-alone Study 2. Heartworm tests and evaluation Blood samples from each animal were collected in potassium EDTA tubes on Days and Statistical analysis The individual dog was the experimental unit. Full size image. Results Laboratory studies Study 1 All animals were dosed uneventfully; no tablets were expelled during or after dosing and no emesis of tablets was noted during post-dosing observations.
Discussion Resistance of heartworms to ML preventatives has been confirmed in both phenotypic efficacy studies and by genetic characterization of individual strains [ 10 , 11 , 13 , 20 , 34 , 35 ]. Availability of data and materials The dataset supporting the conclusions of this article is included within the article. References 1. Article Google Scholar 2. Article Google Scholar 7. Article Google Scholar Google Scholar Acknowledgements The authors would like to thank the support staff at Cheri-Hill Kennel and Supply and at TRS Labs for their assistance with the conduct of the laboratory studies.
Funding These studies were funded by Zoetis, Inc. Ethics declarations Ethics approval and consent to participate The laboratory study protocols were reviewed and approved by the relevant test facility Animal Care and Use Committee prior to implementation. Consent for publication Not applicable. Competing interests These studies were funded by Zoetis.