Formal Verification of Digital Circuits Using Simulator with Mathematical Foundation
Orbeta , Gilberto M. The risks of inclusion: shifts in governance processes and upgrading opportunities for cocoa farmers in Ghana Laven. References Publications referenced by this paper. Whither CSME. The place of Home-Based Enterprises in the household economies of the low-income families in Kumasi: Analysis of contributions and linkages Sam Afrane.
Urban livelihoods—a people-centred approach to reducing poverty Florian Steinberg. Gedeelde smart is halve smart : hoe vrouwen in Paramaribo hun bestaan organiseren Mariska Kromhout. The deductive-bounded approach uses Lyapunov-like certificates with bounded advection of sets to verify the inevitability of phase locking.
The deductive-only technique uses a combination of Lyapunov and Escape certificates to verify the inevitability property. The Sum of Squares SOS programming technique is used to transform the positivity tests of polynomials to the feasibility of semi-definite programs.
The efficacy of the approach is demonstrated by verifying the inevitability of phase locking for a third and fourth order CP PLL. Similarly, the inevitability of oscillation in ring oscillators ROs is verified using a numeric-symbolic deductive approach.
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The global inevitability of oscillation property is specified as a conjunction of several sub-properties that are verified via different Lyapunov-like certificates in different subsets of the state space. Whether such abstraction remains permissible upon addition of an new element to the library or upon changing the cellular microenvironment of the host cell cannot be answered and requires new tests.
With the increase of the library size and the complexity of the desired circuit such procedures soon become infeasible. Biophysical models can be used to predict such host-circuit inferences and gate-gate crosstalks and to ultimately guide us what level of abstraction is permissible. Given this state of affairs, we believe that synthetic biology can profit from concepts, and eventually methods, of EDA and program synthesis from computer science that have reached a considerable sophistication over the last decades see e. We identify the following key aspects that we want to investigate during the seminar and that will also define working groups and according to which we are roughly classifying invitees see Section 3.
In synthetic biology, such robust abstraction has not been defined.
Process spaces and formal verification of asynchronous circuits
Put differently, we were yet not able to optimize biomolecular parts such that they permit a robust Boolean abstraction. We expect that new abstractions will be necessary that can incorporate context-dependencies effects through more expressive interfaces at the part and circuit level.
In order to efficiently study this problem, will require wet-lab and dry-lab synthetic biologists to team up with experts in synthesis of digital circuits, cyber-physical systems and of software. Based on the above considerations, traditional description languages of digital circuits such as Verilog will be insufficient to specify circuit behavior even if the desired circuit should perform Boolean computation.
Beyond the plain Boolean formalisms, temporal logics such as LTL linear temporal logics or STL signal temporal logic have already been used to specify behavior of circuits in systems and synthetic biology. While such languages are powerful enough to express most behaviors required in synthetic biology, they lack features to express the context-dependency of circuits.
For instance, one may wish to specify that the an LTL specification must be met without allocating host cellular resources e. ATPs, ribosomes beyond a certain threshold. In software engineering resource consumptions have been built-in in languages such as ABS abstraction behavioral specification. Hence, to date, no framework exists that meet the requirements of synthetic biology and the proposed seminar will provide the ideal setting to come up with new ideas. Among the invitees are also founders of SBOL Synthetic Biology Open Language that emerges as a standard to specify the parts of a biomolecular circuits.
Verification of Systems and Circuits Using LOTOS, Petri Nets, and CCS | Wiley Online Books
In order to ultimately allow for automatic synthesis tools and adoption in the community any envisioned behavioral specification language needs to be developed in tight coordination with SBOL. The problem of synthesis in synthetic biology has for now been limited to either brute-force sampling and testing of all circuit topologies and parameters or just to the parameter synthesis problem alone.
Parameter synthesis can greatly profit from advanced techniques in machine learning of which we have representatives on our invitation list. On the other hand, formal methods for the synthesis of hardware, software and embedded cyber-physical systems advanced considerably in the last decade .