Biotechnology Annual Review: 13

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Pocket K Pocket Ks are Pockets of Knowledge, packaged information on crop biotechnology products and related issues available at your fingertips. The recent use of sensitive technologies has revealed that DNA methylation dynamics vary considerably between embryonic, germline and somatic cell development, with implications for genetic diseases and cancer.

Review Article 26 July The methylation of arginine residues regulates gene expression, DNA repair, growth factor signalling and liquid—liquid phase separation. Targeting this modification can thus be therapeutically relevant and inhibitors of arginine methylation are being tested in clinical trials, especially for neurodegenerative diseases and cancer.

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Review Article 03 July The dynamic methylation of chromatin components — DNA, histones and RNA — is crucial in development, ageing and cancer. Therapies that target regulators of DNA and histone methylation in cancer have recently been developed.

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These promising therapies, which include strategies that may improve tumour immune surveillance, are already being tested in early-phase clinical trials. Comment 23 September David Jones discusses problems associated with the application of machine learning to biology and advocates for improving publishing standards in this area through a more thorough reporting on the design of the computational experiments.

Research Highlight 23 September The same spliceosome complexes can define both introns and exons; exon definition can cause back-splicing across long exons. Research Highlight 09 September A demonstration of a physiological role of amyloid aggregates in switching on enzymatic activity required for fly development. Research Highlight 30 August Demonstration that active collective cell migration importantly contributes to the movement of intestinal epithelial cells along the villi. Research Highlight 05 August Cytosine methylation m 5 C in mRNAs is important for their transport to distant tissues in plants.

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Journal Club 01 August Emil Heitz was a pioneer of epigenetics at a time when the nature of the heredity material was still unclear. Duke University. Lisbon, Portugal. Storey's Way, Cambridge, United Kingdom.

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Skip to main content. Featured Content Review Article 02 July Roles and regulation of histone methylation in animal development Histone methylation regulates gene expression throughout animal development, governing processes as diverse as cell fate decisions, lineage specification, body patterning and organogenesis. Comment: The importance of non-histone protein methylation in cancer therapy As histone methyltransferase inhibitors are currently being evaluated in clinical trials, the need for better understanding of histone methyltransferases and their potential non-histone substrates is discussed.


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  • Review Article 02 September Control of DNA replication timing in the 3D genome Different genomic regions are replicated at different times during the S phase of the cell cycle, forming early- and late-replicating domains that occupy different locations in the nucleus. Review Article 15 August Advances in protein structure prediction and design Predicting how proteins fold enables inferring their function.

    Biotechnology Annual Review, Volume 13

    Review Article 09 August The diverse roles of DNA methylation in mammalian development and disease DNA methylation is essential for mammalian embryogenesis owing to its repression of transposons and genes, but it is also associated with gene activation. Review Article 26 July The regulation, functions and clinical relevance of arginine methylation The methylation of arginine residues regulates gene expression, DNA repair, growth factor signalling and liquid—liquid phase separation.

    Biotechnology Innovation Organization 2018: Year in Review

    More Reviews More Reviews. Research Highlight 23 September Intron definition, exon definition and back-splicing revisited The same spliceosome complexes can define both introns and exons; exon definition can cause back-splicing across long exons. Research Highlight 09 September Amyloid-directed phosphatase activation A demonstration of a physiological role of amyloid aggregates in switching on enzymatic activity required for fly development.

    Research Highlight 30 August Cryptic migration Demonstration that active collective cell migration importantly contributes to the movement of intestinal epithelial cells along the villi. Journal Club 01 August Emil Heitz, a true epigenetics pioneer Emil Heitz was a pioneer of epigenetics at a time when the nature of the heredity material was still unclear.



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